FAK: A Protein Implicated in Many Diseases (P15754)

Target Name: Focal Adhesion Kinases (FAK)

NCBI ID: P15754

Focal Adhesion Kinases (FAK)

Other Name(s): FAK | Focal Adhesion Kinase

FAK: A Protein Implicated in Many Diseases

Focal Adhesion Kinases (FAK) are a family of transmembrane proteins that are involved in various cellular processes, including cell adhesion, migration, and invasion. They are named for the unique structure of their extracellular domain, which consists of a long, flexible tail that is involved in cell-cell adhesion.

FAK has been implicated in many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its role in these diseases has led to a growing interest in using FAK as a drug target or biomarker.

One of the main challenges in studying FAK is its complex structure and function. The protein is composed of an extracellular tail, a transmembrane domain, and an intracellular domain. The extracellular tail is the longest part of the protein and is involved in cell-cell adhesion. The transmembrane domain is responsible for the protein's movement and interactions with other cells. The intracellular domain is responsible for the protein's interactions with intracellular signaling pathways.

FAK has been shown to play a role in many different cellular processes, including cell adhesion, migration, and invasion. For example, FAK has been shown to be involved in the regulation of cell-cell adhesion, which is important for the development and progression of many diseases, including cancer.

In addition to its role in cell adhesion, FAK has also been shown to be involved in the regulation of cell migration. This is important for the development of many diseases, including neurodegenerative diseases.

FAK has also been shown to be involved in the regulation of cell invasion. This is important for the development of many diseases, including cancer.

The role of FAK in these processes makes it an attractive target for drug development. Researchers are working to develop small molecules that can inhibit the activity of FAK and prevent it from participating in these processes. These small molecules may be used to treat a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its potential as a drug target, FAK is also being studied as a biomarker. This is because its activity can be measured and correlated with the development and progression of many diseases. For example, changes in the level of FAK have been shown to be associated with the development of cancer.

Overall, FAK is a complex protein that plays a role in many cellular processes. Its potential as a drug target and biomarker make it an attractive target for research into the development and treatment of many diseases.

Protein Name: Focal Adhesion Kinases (FAK) (nonspecified Subtype)

The "Focal Adhesion Kinases (FAK) Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about Focal Adhesion Kinases (FAK) comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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